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Alzheimer Disease

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Описание

Contents

Contributing Authors ix

Introduction xiii

Preface xv

Part I. History

1 The Early Story of Alzheimer Disease 1

Katherine L. Bick

Part II. Clinical Presentation

2 Diagnosis 9

Leonard Berg and John C, Morris

3 Noncognitive Symptoms of Alzheimer Disease 27

Marshal F. Folstein and Frederick W. Bylsma

4 Neuropsychological Features of Memory Disorders in

Alzheimer Disease 41

Mark W. Bondi, David P. Salmon, and Nelson M. Butters

5 Clinical Genetics of Familial Alzheimer Disease 65

Thomas D. Bird

6 Neuroimaging with CT and MRI in Alzheimer Disease 75

Ranjan Duara

7 PET Imaging 87

Norman L. Foster

Part III. Epidemiology

8 The Epidemiology of Dementia and Alzheimer Disease 105

Robert Katz,man and Claudia H. Kawas

Part IV. Confounding Disorders

9 Dementia Associated with Cerebrovascular Disease, Other Degenerative

Diseases, and Metabolic Disorders 123

Thomas K. Tatemichi, Ned Sacktor, and Richard Mayeux

10 Pathology of the Other Dementias 167

Lawrence A. Hansen

Fart V. Anatomical Pathology

11 Structural Basis of the Cognitive Alterations in Alzheimer Disease 179

Robert D. Terry, Eliezer Masliah, and Lawrence A. Hansen

12 The Cellular Basis of Cortical Disconnection in Alzheimer Disease and

Related Dementing Conditions 197

Patrick R. Hof and John H. Morrison

13 The Aged Nonhuman Primate: A Model for the Behavioral and Brain

Abnormalities Occurring in Aged Humans 231

Donald L. Price, Lee J. Martin, Sang ram S. S isodia,

Lary C. Walker, Mary Lou Voytko, Molly V. Wagster,

Linda C. Cork, and Vassilis E. Koliatsos

Part VI. Biochemical Pathology

14 Neurotransmitters and Neuropeptides 247

Paul T. Francis, Alan J. Cross, and David M. Bowen

15 Cholinergic Systems and Related Neuropathological Predilection Patterns

in Alzheimer Disease 263

Changiz Geula and M.-Marsel Mesulam

16 Neurotransmitter Receptors in Alzheimer Disease 293

Anne B. Young and John B. Penney, Jr.

17 0-Amyloid and Its Contributions to Neurodegeneration in Alzheimer

Disease 305

Carl W. Cotman and Christian J. Pike

18 0-Amyloid and Amyloid Precursor Protein: Chemistry, Molecular Biology,

and N europathology 317

Nikolaos K. Robakis

19 Neuronal Abnormalities, Not Amyloid, Are the Cause of Dementia in

Alzheimer Disease 327

Peter Davies

20 Tau Protein and Alzheimer Disease 335

Kenneth S. Kosik and Steven M. Greenberg

21 The Molecular Genetics of Alzheimer Disease 345

Peter H. St George-Hyslop

22 Brain Trace Elements in Alzheimer Disease 353

William R. Markesbery and William D. Ehmann

23 The Role of Membranes and Energetics in Alzheimer Disease 369

Jay W. Pettegrew, Richard J. McClure, Julian N. Kanfer,

R. Preston Mason, Kanagasabai Panchalingam, and William E. Klunk

24 Altered Signal Transduction in Alzheimer Disease 387

Karen Horsburgh and Tsunao Saitoh

25 Neurotrophic Factors and Neuronal Loss: Potential Relevance to

Alzheimer Disease 405

Part VII, Clinical Management

26 Noncognitive Symptoms in Alzheimer Disease: Definitions, Treatments,

Peter V. Rabins

27 Clinical Trials in Alzheimer Disease 431

LeonJ. Thai

28 The Prospect on Developing Treatments for Alzheimer Disease 445

Zaven S. Khachaturian, Creighton H. Phelps, and

Neil S. Buckholtz

Note Added in Proof: Apolipoprotein E4 as the Major Genetic

Susceptibility Factor for Alzheimer Disease 455

Robert Katzman

Subject Index . 459