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Alzheimer Disease

Alzheimer Disease

Сумата се прибавя директно в кошницата

Contributing Authors ix
Introduction xiii
Preface xv
Part I. History
1 The Early Story of Alzheimer Disease 1
Katherine L. Bick
Part II. Clinical Presentation
2 Diagnosis    9
Leonard Berg and John C, Morris
3 Noncognitive Symptoms of Alzheimer Disease 27
Marshal F. Folstein and Frederick W. Bylsma
4 Neuropsychological Features of Memory Disorders in
Alzheimer Disease        41
Mark W. Bondi, David P. Salmon, and Nelson M. Butters
5 Clinical Genetics of Familial Alzheimer Disease 65
Thomas D. Bird
6 Neuroimaging with CT and MRI in Alzheimer Disease 75
Ranjan Duara
7 PET Imaging        87
Norman L. Foster
Part III. Epidemiology
8 The Epidemiology of Dementia and Alzheimer Disease   105
Robert Katz,man and Claudia H. Kawas
Part IV. Confounding Disorders
9 Dementia Associated with Cerebrovascular Disease, Other Degenerative
Diseases, and Metabolic Disorders 123
Thomas K. Tatemichi, Ned Sacktor, and Richard Mayeux
10 Pathology of the Other Dementias      167
Lawrence A. Hansen


Fart V. Anatomical Pathology
11 Structural Basis of the Cognitive Alterations in Alzheimer Disease 179
Robert D. Terry, Eliezer Masliah, and Lawrence A. Hansen
12 The Cellular Basis of Cortical Disconnection in Alzheimer Disease and
Related Dementing Conditions 197
Patrick R. Hof and John H. Morrison
13 The Aged Nonhuman Primate: A Model for the Behavioral and Brain
Abnormalities Occurring in Aged Humans 231
Donald L. Price, Lee J. Martin, Sang ram S. S isodia,
Lary C. Walker, Mary Lou Voytko, Molly V. Wagster,
Linda C. Cork, and Vassilis E. Koliatsos
Part VI. Biochemical Pathology
14 Neurotransmitters and Neuropeptides 247
Paul T. Francis, Alan J. Cross, and David M. Bowen
15 Cholinergic Systems and Related Neuropathological Predilection Patterns
in Alzheimer Disease 263
Changiz Geula and M.-Marsel Mesulam
16 Neurotransmitter Receptors in Alzheimer Disease 293
Anne B. Young and John B. Penney, Jr.
17 0-Amyloid and Its Contributions to Neurodegeneration in Alzheimer
Disease 305
Carl W. Cotman and Christian J. Pike
18 0-Amyloid and Amyloid Precursor Protein: Chemistry, Molecular Biology,
and N europathology     317
Nikolaos K. Robakis
19 Neuronal Abnormalities, Not Amyloid, Are the Cause of Dementia in
Alzheimer Disease        327
Peter Davies
20 Tau Protein and Alzheimer Disease 335
Kenneth S. Kosik and Steven M. Greenberg
21 The Molecular Genetics of Alzheimer Disease 345
Peter H. St George-Hyslop
22 Brain Trace Elements in Alzheimer Disease 353
William R. Markesbery and William D. Ehmann
23 The Role of Membranes and Energetics in Alzheimer Disease 369
Jay W. Pettegrew, Richard J. McClure, Julian N. Kanfer,
R. Preston Mason, Kanagasabai Panchalingam, and William E. Klunk
24 Altered Signal Transduction in Alzheimer Disease 387
Karen Horsburgh and Tsunao Saitoh
25 Neurotrophic Factors and Neuronal Loss: Potential Relevance to
Alzheimer Disease 405


Part VII, Clinical Management

26 Noncognitive Symptoms in Alzheimer Disease: Definitions, Treatments,

Peter V. Rabins
27 Clinical Trials in Alzheimer Disease 431
LeonJ. Thai
28 The Prospect on Developing Treatments for Alzheimer Disease 445
Zaven S. Khachaturian, Creighton H. Phelps, and
Neil S. Buckholtz
Note Added in Proof: Apolipoprotein E4 as the Major Genetic
Susceptibility Factor for Alzheimer Disease 455
Robert Katzman
Subject Index . 459