CONTENTS
PART I BASIC PRINCIPLES PHARMACOKINETICS PHARMACODYNAMICS 9
1. DRUGS IN MEDICINE: INTRODUCTION TO PHARMACOLOGY - Nadka Boyadjieva 10
2. ROUTES OF DRUG ADMINISTRATION - Nadka Boyadjieva 12
3. ABSORPTION OF DRUGS - Nadka Boyadjieva 20
4. DRUG DISTRIBUTION - Nadka Boyadjieva : 24
5. METABOLISM OF DRUGS - Nadka Boyadjieva 29
6. EXCRETION OF DRUGS -Nadka Boyadjieva 35
7. PHARMACOKINETIC PARAMETERS -Nadka Boyadjieva... 38
8. PHARMACODYNAMICS (PART I) - Nadka Boyadjieva 43
9. PHARMACODYNAMICS (PART II) - Nadka Boyadjieva ! 51
10. PHARMACODYNAMIC (PART III) - Nadka Boyadjieva 57
11. PHARMACOGENETICS AND PHARMACOGENOMICS - Nadka Boyadjieva 63
12. DRUG INTERACTIONS - Pavlina Andreeva-Gateva 69
PART II DRUGS AFFECTING THE CENTRAL AND PERIFERAL NERVOUS SYSTEM..... 75
13. HYPNOTIC DRUGS - Nadka Boyadjieva 76
14. ANXIOLYTIC DRUGS-Nadka Boyadjieva 80
15. DRUGS USED IN THE TREATMENT OF PSYCHOSES - Damianka Getova : 87
16. ANTIDEPRESSANT DRUGS - Miroslava Varadinova 92
17. ANTIEPILEPTIC DRUGS - Evgeni. Haritov : 98
18. DRUG USED IN PARKINSONISM-Nadka Boyadjieva 104
19. CHOLINERGIC NEUROTRANSMISSION. CHOLINOMIMETICS (CHOLINERGIC AGONISTS).
MUSCARINIC ANTAGONISTS. NEUROMUSCULAR BLOCKING AGENTS -Krassimira Yakimova.. 109
20. SYMPATHOMIMETICS AND SYMPATHOLYTICS - Pavlina Andreeva-Gateva ; 116
21. HISTAMINE AND ANTAGONISTS - Anna Bclchcva 129
22. SEROTONIN (5-HYDROXYTRYPTAMINE) - Anna Relcneva 133
23. NONSTEROIDAL ANTIINFLAMMATORY DRUGS - Maria Zhelyazkova-Savova 137
24. ANALGESICS ANTIPIRETICS (NON-OPIOID ANALGESICS) - Maria Zhelyazkova-Savova 142
25. PAIN AND OPIOID ANALGESICS - Diana Pendicheva and Ivan Lambev 144
26. LOCAL ANESTHETICS - Lyudmil Peychev 152
PART III DRUGS AFFECTING MAJOR ORGAN SYSTEMS 157
27. DRUGS USED IN HEART FAILURE - Pavlina Andreeva-Gateva 158
28. ANTIARRHYTHMIC DRUGS - Irina Nikolova and Nikolai Danchev 167
29. DRUG USED IN CARDIAC ISCHEMIA (ANTI ANGINAL DRUGS) - Irina Nikolova and Nikolai Danchev 172
30. DRUGS USED IN H YPERTENSION - Irina Nikolova and Nikolai Danchev 177
31. DIURETICS - Katerina Simeonova : 183
32. HEMATOPOIETIC DRUGS - Stefka Valcheva-Kuzmanova 189
33. ANTICOAGULANT DRUGS - Evgeni Haritov : 195
34. COAGULANTS. DRUGS AFFECTING THE FIBRINOLYTIC SYSTEM-Nadka Boyadjieva 200
35. DRUGS USED IN HYPERLIPIDEMIA - Georgi Bogdanov 207
36. DRUGS AFFECTING RESPIRATORY SYSTEM - Tzvetanka Markova 210
8 / Pharmacology
37. GASTROINTESTINAL PHARMACOLOGY DRUGS USED TO TREAT PEPTTC ULCER DISEASE - Rumen Nikolov... 216
38. ANTIEMETICS. LAXATIVES - Rumen Nikolov 220
LAXATIVES — Rumen Nikolov 221
39. PROBIOTICS (DIETARY SUPPLEMENTS) - Georgi Bogdanov 225
40. ANTI-OBESITY DRUGS - Teodora Handjieva-Darlenska 227
41. ANTIDIABETIC DRUGS - Teodora Handjieva-Darlenska 229
42. THYROID AND ANTITHYROID DRUGS - Georgi Bogdanov 234
43. GONADAL HORMONES & INHIBITORS - Nadka Boyadjicva 237
PART IV CHEMOTHERAPEUTIC DRUGS IMMUNOMODULATORS 243
44. PENICILLINS - Georgeia Bocheva 244
45. CEPHALOSPORINS. CARBAPENEMS AND MONOBACTAMS - Nadka Boyadjieva 250
46. AMINOGLYCOSIDES - Rumen Nikolov 255
47. TETRACYCLINES - Rumen Nikolov . 258
48. MACROLIDE ANTIBIOTICS - Slavina Surcheva 261
49. ANTIMY'COBACTERIAL DRUGS - Galya Stavreva and Diana Pendicheva-Duhlenska 264
50. QUINQLQNES - DNA GYRASE INHIBITORS. FLUOROQUINOLONES — Georgeta Bocheva 269
■ 51. ANTIFUNGAL DRUGS - Evgeni Haritov 272
52. ANTIVIRAL DRUGS - Irina Nikoiova and Nikolai Danchev 276
53. DRUGS USED FOR SPECIFIC CANCER TREATMENT (ANTICANCER DRUGS) - Damiaka Getova 281
54. DRUGS MODIFYING BIOLOGICAL RESPONSE
(DRUGS FOR NON SPECIFIC ANTICANCER TREATMENT) - Damianka Getova. 286
55. IMMUNOMODULATORS: IMMUNOACTIVATORS - Nadka Boyadjieva and Zorina Petrova 289
56. IMMUNOSUPPRESSIVE DRUGS - Evgeni Haritov 294
57. ANTISEPTICS AND DISINFECTANTS - Slavina Surcheva 299
58. ANTIMICROBIAL DRUGS WITH SPECIFIC AND LIMITED USAGE - D. Getova 303
59. DRUGS FOR THE TREATMENT OF AUTOIMMMUNE DISEASES: GLUCOCORTICOIDS - Nadka Boyadjieva 305
PART V CLINICAL PHARMACOLOGY 313
60. CLINICAL PHARMACOLOGY AS A MEDICAL DISCIPLINE - Emil Gatchev 314
61. RATIONAL DRUG PRESCRIBING - Emil Gatchev 315
62. RATIONAL DRUG USE - Emil Gatchev and Dobrin Svinarov 318
63. DRUG SAFETY-Emil Gatchev 323
64. ECONOMIC ASPECTS OF PHARMACOTHERAPY-PHARMACOECONOM1CS - Emil Gatchev 328
65. CLINICAL DRUG TRIALS - Emil Gatchev and Rossen Koytchev 331
66. THERAPEUTIC DRUG MANAGEMENT - Dobrin Svinarov
PART VI TOXICOLOGY 347
67. INTRODUCTION TO MEDICAL TOXICOLOGY - Nadka Boyadjieva 348
68. EMBRIOTOXICITY AND TERATOGENICITY OF DRUGS - Maria Traykova and Nadka Boyadjieva 352
69. GENOTOXICITY, MUTAGENESIS AND CANCEROGENESIS OF DRUGS - Maria Traykova, and Nadka Boyadjieva362
70. DRUG INTERACTIONS IN TOXICOLOGY - Maria Traykova, and Nadka Boyadjieva 368
71. HOMEOPATHY IN MEDICINE - Slavi Fitchev, Maryan Ivanov. Rayna Tomova and Zorka Ugririova 378
INDEX OF DRUGS'- Galina Dobrevska and Katerina Simeonova 382