Contents
General Pharmacology 1
History of Pharmacology 2
Drug Sources
Drug and Active Principle 4
Drug Development 6
Drug Administration
Dosage Forms for Oral, and Nasal Applications 8
Dosage Forms for Parenteral Pulmonary 12
Rectal or Vaginal, and Cutaneous Application 12
Drug Administration by Inhalation 14
Dermatalogic Agents 16
From Application to Distribution 18
Cellular Sites of Action
Potential Targets of Drug Action 20
Distribution in the Body
External Barriers of the Body 22
Blood-Tissue Barriers 24
Membrane Permeation 26
Possible Modes of Drug Distribution 28
Binding to Plasma Proteins 30
Drug Elimination
The Liver as an Excretory Organ 32
Biotransformation of Drugs 34
Enterohepatic Cycle 38
The Kidney as Excretory Organ 40
Elimination of Lipophilic and Hydrophilic Substances 42
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